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🏃Endurance

Cardarine

Cardarine (GW-501516) is known for its potential to enhance endurance and fat oxidation during exercise.

Clinical Dose: 0mgFound in: 4 products

What Does Cardarine Do?

Cardarine, also known as GW-501516, is a PPARδ (Peroxisome Proliferator-Activated Receptor delta) receptor agonist that fundamentally changes how your body utilizes energy during physical exertion. Unlike traditional stimulants, it works by activating the same genetic pathways triggered through high-intensity aerobic exercise, effectively "mimicking" cardio at a cellular level to shift the body's fuel source.

  • Massive Endurance Boost: By increasing oxygen uptake and expression of genes involved in energy expenditure, Cardarine allows you to push through plateaus and significantly extend your time to exhaustion.
  • Enhanced Fat Oxidation: It signals the body to prioritize burning stored body fat for energy instead of glucose, making it a potent tool for body recomposition and cutting phases.
  • Improved Recovery: By optimizing metabolic efficiency and reducing the inflammatory response to training, it shortens the time needed between high-intensity sets or daily sessions.
  • Lipid Profile Support: Originally developed to treat cardiovascular disease, it has been shown in various studies to increase HDL (good) cholesterol while lowering triglycerides.

Clinical vs. Gym Bro Dosing

Because Cardarine was never FDA-approved for human use, "clinical" doses are derived from abandoned medical trials and anecdotal evidence from the athletic community.

TierDoseNotes
Threshold5mgMinimal dose for slight endurance improvements and lipid support.
Performance10mgThe standard dose used by most athletes for noticeable fat loss.
Maximum20mgHigh-end dose often used for aggressive cutting cycles; higher risk.

Key Insight: While the official recommended dosage is 0.00mg because it is classified as a research chemical, most anecdotal reports suggest that a single daily dose of 10mg is the "sweet spot" for performance without reaching the extreme levels used in controversial animal studies.

Side Effects & Warnings

  • Carcinogenicity Concerns: The primary reason development of Cardarine stopped was due to rodent studies where extremely high, long-term doses caused rapid tumor growth.
  • Liver Stress: While not as toxic as oral steroids, some users may experience a mild elevation in liver enzymes during extended cycles.
  • WADA Prohibited: Cardarine is strictly banned by WADA and most athletic commissions under the category of "Hormone and Metabolic Modulators."

Contraindications: You should avoid Cardarine if you have a personal or family history of cancer. It is not a stimulant, but it should not be stacked with other experimental metabolic modulators without extreme caution.