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L-norvaline

L-norvaline inhibits arginase, which can help sustain higher levels of arginine for enhanced nitric oxide production and muscle pump.

Clinical Dose: 200mgFound in: 51 products

What Does L-Norvaline Do?

L-norvaline is a non-proteinogenic amino acid that acts as a powerful arginase inhibitor, ensuring your body doesn't prematurely break down the ingredients meant to give you a pump. By blocking the enzyme responsible for degrading arginine, it allows for significantly higher and more sustained nitric oxide production throughout your training session.

  • Arginase Inhibition: It effectively shuts down the arginase enzyme, which normally converts arginine into urea, keeping more arginine available for nitric oxide synthesis.
  • Sustained Muscle Pumps: While ingredients like Citrulline provide the fuel, Norvaline acts as the "security guard," preventing the breakdown of NO precursors for longer-lasting muscle fullness.
  • Enhanced Nutrient Delivery: By promoting vasodilation for extended periods, it helps shuttle oxygen and vital nutrients to working muscle tissues more efficiently during high-intensity sets.
  • Synergistic Potency: It creates a multi-pathway approach to blood flow when paired with L-citrulline or Agmatine, making your existing pump ingredients work twice as hard.

Clinical vs. Gym Bro Dosing

TierDoseNotes
Minimum50mgOften found in underdosed proprietary blends; provides minimal effect.
Standard100mg - 150mgCommon in many moderate-stim pre-workouts to support blood flow.
Clinical200mgThe recommended sweet spot for effective, noticeable arginase inhibition.
Performance250mg+High-end dosage found in premium, "max-pump" focused formulations.

Key Insight: L-norvaline is not a standalone pump ingredient; its primary value is as an "amplifier." You should always look for it in formulas that already contain at least 6g of L-Citrulline to ensure there is enough arginine available for the Norvaline to actually protect.

Side Effects & Warnings

  • Lightheadedness: Because L-norvaline is highly effective at promoting vasodilation and lowering blood pressure, some users may experience dizziness if they stand up too quickly during a workout.
  • Digestive Discomfort: In rare cases, or at dosages exceeding 400mg, users have reported mild nausea or stomach cramping.
  • Vasodilation Sensitivity: Those with naturally low blood pressure may find the increased blood flow leads to a temporary feeling of fatigue.

Tip: If you are new to potent vasodilators, start with a half-serving of your pre-workout to assess how your blood pressure reacts to the sustained nitric oxide boost.