Back to Ingredient Index
💪Pump
L-citrulline
L-citrulline is a precursor to nitric oxide, which increases blood flow to the muscles.
Clinical Dose: 6gFound in: 442 products
What Does L-Citrulline Do?
L-Citrulline is a non-essential amino acid that converts to L-Arginine in the kidneys, boosting nitric oxide (NO) production. It is the gold standard pump ingredient.
- Enhanced Blood Flow: Increases nitric oxide, promoting vasodilation and the "pump" during training.
- Reduced Fatigue: Helps clear ammonia from the bloodstream, delaying muscular fatigue.
- Improved Endurance: Studies show significant increases in time-to-exhaustion and rep performance.
- Better Nutrient Delivery: Improved blood flow means more oxygen and nutrients reach working muscles.
Clinical vs. Gym Bro Dosing
| Tier | Dose | Notes |
|---|---|---|
| Clinical Minimum | 3,000 mg | Threshold for measurable NO increase |
| Standard Effective | 6,000 mg | The research-backed dose for performance |
| High Performance | 8,000–10,000 mg | Used in mega-dose pump formulas |
| Citrulline Malate 2:1 | 8,000 mg | Provides ~5,300 mg pure citrulline |
Key Insight: Pure L-Citrulline at 6g is superior to Citrulline Malate for nitric oxide production. If a product uses Citrulline Malate 2:1, you need 8–9g to match.
Side Effects & Warnings
- Generally Well-Tolerated: L-Citrulline has an excellent safety profile at standard doses.
- Mild GI Discomfort: Some users report bloating or stomach upset at very high doses (10g+).
- Blood Pressure: May lower blood pressure. Those on antihypertensives should monitor accordingly.
Contraindications: Consult a physician if you are on blood pressure medication or nitrate drugs.
Top Products Containing L-citrulline
Sorted by popularity. Dosage shown per serving.
Page 1 of 7