What are the side effects of l-citrulline?

- Generally Well-Tolerated: L-Citrulline has an excellent safety profile at standard doses.

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l-citrulline

Q: What is the recommended dosage of l-citrulline?

Key Insight: Pure L-Citrulline at 6g is superior to Citrulline Malate for nitric oxide production. If a product uses Citrulline Malate 2:1, you need 8–9g to match.

L-citrulline is a precursor to nitric oxide, which increases blood flow to the muscles.

Clinical Dose: 6gFound in: 100 products

What Does L-Citrulline Do?

L-Citrulline is a non-essential amino acid that converts to L-Arginine in the kidneys, boosting nitric oxide (NO) production. It is the gold standard pump ingredient.

Enhanced Blood Flow: Increases nitric oxide, promoting vasodilation and the "pump" during training.
Reduced Fatigue: Helps clear ammonia from the bloodstream, delaying muscular fatigue.
Improved Endurance: Studies show significant increases in time-to-exhaustion and rep performance.
Better Nutrient Delivery: Improved blood flow means more oxygen and nutrients reach working muscles.

Clinical vs. Gym Bro Dosing

Tier	Dose	Notes
Clinical Minimum	3,000 mg	Threshold for measurable NO increase
Standard Effective	6,000 mg	The research-backed dose for performance
High Performance	8,000–10,000 mg	Used in mega-dose pump formulas
Citrulline Malate 2:1	8,000 mg	Provides ~5,300 mg pure citrulline

Key Insight: Pure L-Citrulline at 6g is superior to Citrulline Malate for nitric oxide production. If a product uses Citrulline Malate 2:1, you need 8–9g to match.

Side Effects & Warnings

Generally Well-Tolerated: L-Citrulline has an excellent safety profile at standard doses.
Mild GI Discomfort: Some users report bloating or stomach upset at very high doses (10g+).
Blood Pressure: May lower blood pressure. Those on antihypertensives should monitor accordingly.

Contraindications: Consult a physician if you are on blood pressure medication or nitrate drugs.